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LY329146

Catalog No.: A61033
MRP1 Inhibitor
LY329146 is a selective inhibitor of multidrug resistance protein 1 (MRP1). It effectively inhibits the transport of leukotriene C4 (LTC4) with an IC50 of 0.8 μM. This compound is valuable for studies exploring multidrug resistance mechanisms and may have applications in enhancing the efficacy of chemotherapy in resistant cancer cells.
LY329146 191043-78-4 MRP1 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLY329146 is a selective inhibitor of multidrug resistance protein 1 (MRP1). It effectively inhibits the transport of leukotriene C4 (LTC4) with an IC50 of 0.8 μM. This compound is valuable for studies exploring multidrug resistance mechanisms and may have applications in enhancing the efficacy of chemotherapy in resistant cancer cells.
Product Information
Catalog NumA61033
FormulaC30H32N2O7S3
Molecular Weight628.78
CAS Number191043-78-4
SMILESCS(=O)(N(C1=CC=C(C2=C(C(C3=CC=C(OCCN4CCCCC4)C=C3)=O)C5=CC=C(O)C=C5S2)C=C1)S(=O)(C)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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GPCR/G Protein > Leukotriene Receptor