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Biological Activity
LY 341495 has been shown to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8 , mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.3 mL | 141.49 mL | 282.99 mL |
| 0.5 mM | 5.66 mL | 28.3 mL | 56.6 mL |
| 1 mM | 2.83 mL | 14.15 mL | 28.3 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
*The above data is based on the productmolecular weight 353.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11484 |
|---|---|
| Actions | Antagonist |
| CAS No. | 201943-63-7 |
| Formula | C20H19NO5 |
| M. Wt | 353.37 |
| Purity | >98% |
| SMILES | C1[[email protected]@H]([[email protected]]1[[email protected]@](CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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