m-PEG4-Br is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs) for enhanced therapeutic efficacy. By distally connecting to the monomethyl auristatin E (MMAE) payload, m-PEG4-Br modulates hydrophilicity, antigen binding, and in vitro potency of the ADC. Additionally, this versatile compound serves as a PROTAC linker, facilitating the development of PROTACs for targeted protein degradation studies.
m-PEG4-Br is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs) for enhanced therapeutic efficacy. By distally connecting to the monomethyl auristatin E (MMAE) payload, m-PEG4-Br modulates hydrophilicity, antigen binding, and in vitro potency of the ADC. Additionally, this versatile compound serves as a PROTAC linker, facilitating the development of PROTACs for targeted protein degradation studies.
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