M1069 is a selective, orally active dual antagonist of the A2A and A2B adenosine receptors, demonstrating over 100-fold selectivity against the A1 and A3 receptors. This compound effectively counteracts the immune-suppressive mechanisms mediated by adenosine, making it valuable in cancer research. Additionally, M1069 shows promise for anti-tumor activity, supporting its potential use in therapeutic strategies aimed at enhancing immune responses in tumor microenvironments.
M1069 is a selective, orally active dual antagonist of the A2A and A2B adenosine receptors, demonstrating over 100-fold selectivity against the A1 and A3 receptors. This compound effectively counteracts the immune-suppressive mechanisms mediated by adenosine, making it valuable in cancer research. Additionally, M1069 shows promise for anti-tumor activity, supporting its potential use in therapeutic strategies aimed at enhancing immune responses in tumor microenvironments.
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