Macitentan

Catalog No.: A11492

Endothelin receptor antagonist

Macitentan Chemical Structure

CAS NO. 441798-33-0

Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$65.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Targets
ET-A ET-B
0.5 nM391 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17 mL 84.99 mL 169.99 mL
0.5 mM 3.4 mL 17 mL 34 mL
1 mM 1.7 mL 8.5 mL 17 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 588.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11492
Actions Antagonist
M. Wt 588.27
Formula C19H20Br2N6O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 441798-33-0
Synonyms ACT 064992, ACT-064992, ACT064992
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br

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