Macitentan

Catalog No.: A11492

Endothelin receptor antagonist

Macitentan

Macitentan Chemical Structure

CAS NO. 441798-33-0

Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

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5 mg

Regular Price: $45.00

Special Price $36.00

10 mg

Regular Price: $65.00

Special Price $52.00

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Biological Activity

Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Targets
ET-A ET-B
0.5 nM391 nM
In vitro DMSO 87 mg/mL (147.88 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17 mL 84.99 mL 169.99 mL
0.5 mM 3.4 mL 17 mL 34 mL
1 mM 1.7 mL 8.5 mL 17 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 588.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11492
Actions Antagonist
CAS No. 441798-33-0
Formula C19H20Br2N6O4S
M. Wt 588.27
Purity >98%
Synonyms ACT 064992, ACT-064992, ACT064992
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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