MAO-B-IN-21 is a potent inhibitor of monoamine oxidase B (MAO-B) that also demonstrates antioxidant properties. This compound exhibits anti-amyloid-beta (Aβ) aggregation activity, metal-ion chelation, and anti-neuroinflammatory effects, specifically targeting nitric oxide and TNF-α pathways. Additionally, MAO-B-IN-21 is neuroprotective and can cross the blood-brain barrier. Its efficacy in enhancing memory and cognitive function has been established in a mouse model of Alzheimer’s disease induced by Aβ1-42.
MAO-B-IN-21 is a potent inhibitor of monoamine oxidase B (MAO-B) that also demonstrates antioxidant properties. This compound exhibits anti-amyloid-beta (Aβ) aggregation activity, metal-ion chelation, and anti-neuroinflammatory effects, specifically targeting nitric oxide and TNF-α pathways. Additionally, MAO-B-IN-21 is neuroprotective and can cross the blood-brain barrier. Its efficacy in enhancing memory and cognitive function has been established in a mouse model of Alzheimer’s disease induced by Aβ1-42.
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