MAO-B-IN-30 is a selective inhibitor of monoamine oxidase B (MAO-B) that effectively crosses the blood-brain barrier, with IC50 values of 19.176 µM for MAO-A and 0.082 µM for MAO-B. This compound exhibits significant antiproliferative activity while demonstrating non-cytotoxic effects. Additionally, MAO-B-IN-30 effectively reduces pro-inflammatory cytokines, including TNF-alpha and IL-6, as well as the NF-kB pathway. Its properties make it a valuable tool for research into the mechanisms underlying Parkinson's disease.
MAO-B-IN-30 is a selective inhibitor of monoamine oxidase B (MAO-B) that effectively crosses the blood-brain barrier, with IC50 values of 19.176 µM for MAO-A and 0.082 µM for MAO-B. This compound exhibits significant antiproliferative activity while demonstrating non-cytotoxic effects. Additionally, MAO-B-IN-30 effectively reduces pro-inflammatory cytokines, including TNF-alpha and IL-6, as well as the NF-kB pathway. Its properties make it a valuable tool for research into the mechanisms underlying Parkinson's disease.
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