MAO-B-IN-39 is a selective monoamine oxidase B (MAO-B) inhibitor that demonstrates an IC50 of 3.61 μM. It exhibits potent induction of NRF2, contributing to its significant anti-inflammatory and neuroprotective effects in oxidative stress-related in vitro models. Additionally, MAO-B-IN-39 has shown high liver microsomal stability and favorable pharmacokinetics in murine studies, indicating its potential utility in Parkinson's disease research.
MAO-B-IN-39 is a selective monoamine oxidase B (MAO-B) inhibitor that demonstrates an IC50 of 3.61 μM. It exhibits potent induction of NRF2, contributing to its significant anti-inflammatory and neuroprotective effects in oxidative stress-related in vitro models. Additionally, MAO-B-IN-39 has shown high liver microsomal stability and favorable pharmacokinetics in murine studies, indicating its potential utility in Parkinson's disease research.
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