MAO-B-IN-53 is a selective inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 of 0.066 μM. This compound demonstrates mixed reversible inhibition and binding stability at the hMAO-B active site, while displaying a high selectivity for hMAO-B over hMAO-A. Due to its neuroprotective properties, MAO-B-IN-53 has been shown to mitigate 6-OHDA-induced cellular damage with minimal neurotoxicity in neuroblastoma cells, making it a valuable reagent for research into Parkinson's disease.
MAO-B-IN-53 is a selective inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 of 0.066 μM. This compound demonstrates mixed reversible inhibition and binding stability at the hMAO-B active site, while displaying a high selectivity for hMAO-B over hMAO-A. Due to its neuroprotective properties, MAO-B-IN-53 has been shown to mitigate 6-OHDA-induced cellular damage with minimal neurotoxicity in neuroblastoma cells, making it a valuable reagent for research into Parkinson's disease.
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