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Mast cell degranulating peptide (28-49)

Catalog No.: A66148
Depolarizing Agent
Mast cell degranulating peptide (28-49) is a depolarizing agent derived from bee venom that acts on mast cells to induce degranulation. It has been shown to elevate cyclic guanosine monophosphate (cGMP) levels in mouse cerebellar slices, implicating its role in modulating neurotransmission and signaling pathways. This peptide is valuable for research applications focused on mast cell biology and the study of neuropharmacological effects.
Mast cell degranulating peptide (28-49) 65636-54-6 Depolarizing Agent
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMast cell degranulating peptide (28-49) is a depolarizing agent derived from bee venom that acts on mast cells to induce degranulation. It has been shown to elevate cyclic guanosine monophosphate (cGMP) levels in mouse cerebellar slices, implicating its role in modulating neurotransmission and signaling pathways. This peptide is valuable for research applications focused on mast cell biology and the study of neuropharmacological effects.
Product Information
Catalog NumA66148
FormulaC110H196N40O24S4
Molecular Weight2591.25
CAS Number65636-54-6
SequenceIle-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2
Sequence shorteningIKCNCKRHVIKPHICRKICGKN-NH2
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CCCCN)=O)CS)=O)CC(N)=O)=O)CS)=O)CCCCN)=O)CCCNC(=N)N)=O)=O)[C@@H](C)C)=O)[C@H](CC)C)=O)CCCCN)(=O)N2[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CCCCN)=O)=O)CS)=O)[C@H](CC)C)=O)CCCCN)=O)CCCNC(=N)N)=O)CS)=O)[C@H](CC)C)=O)=O)CCC2
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