Mavacamten-d1 is a deuterium-labeled derivative of Mavacamten, a selective modulator of cardiac myosin that interacts with myosin to reduce cardiac contractility. This compound exhibits significant inhibitory activity with IC50 values of 490 nM for bovine cardiac myosin and 711 nM for human cardiac myosin. Mavacamten-d1 is valuable for metabolic studies, pharmacokinetic assessments, and other research applications requiring stable isotopes in cardiac function investigations.
Mavacamten-d1 is a deuterium-labeled derivative of Mavacamten, a selective modulator of cardiac myosin that interacts with myosin to reduce cardiac contractility. This compound exhibits significant inhibitory activity with IC50 values of 490 nM for bovine cardiac myosin and 711 nM for human cardiac myosin. Mavacamten-d1 is valuable for metabolic studies, pharmacokinetic assessments, and other research applications requiring stable isotopes in cardiac function investigations.
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