Maytansine derivative M24

Catalog No.: A41538
Drug-Linker Conjugates for ADC
Maytansine derivative M24 is a potent drug-linker conjugate targeting the development of antibody-drug conjugates (ADCs). It plays a crucial role in synthesizing ADCs, specifically REGN5093-M114, leveraging its mechanism of action for selective cytotoxicity in targeted cancer therapies. This compound is essential for researchers focused on enhancing therapeutic efficacy while minimizing off-target effects in oncology applications.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMaytansine derivative M24 is a potent drug-linker conjugate targeting the development of antibody-drug conjugates (ADCs). It plays a crucial role in synthesizing ADCs, specifically REGN5093-M114, leveraging its mechanism of action for selective cytotoxicity in targeted cancer therapies. This compound is essential for researchers focused on enhancing therapeutic efficacy while minimizing off-target effects in oncology applications.
Product Information
Catalog NumA41538
FormulaC61H86ClN9O18
Molecular Weight1268.84
CAS Number2226467-81-6
SMILESC[C@]12[C@H]([C@@H]([C@@H]3C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCN(C)C(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@@H](NC(CCCCC(O)=O)=O)C(C)C)=O)=O)C=C5)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)O1
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