MC-SN38 is a drug-linker conjugate that combines the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for the development of antibody-drug conjugates (ADCs). SN38, a bioactive metabolite of the Topoisomerase I inhibitor Irinotecan, exerts its biological activity by inhibiting DNA synthesis and inducing DNA single-strand breaks. This compound is essential for research into targeted cancer therapies that leverage the specificity of antibodies to deliver cytotoxic agents to tumor cells.
MC-SN38 is a drug-linker conjugate that combines the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for the development of antibody-drug conjugates (ADCs). SN38, a bioactive metabolite of the Topoisomerase I inhibitor Irinotecan, exerts its biological activity by inhibiting DNA synthesis and inducing DNA single-strand breaks. This compound is essential for research into targeted cancer therapies that leverage the specificity of antibodies to deliver cytotoxic agents to tumor cells.
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