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MD-224

Catalog No.: A18712
MDM2 degrader
Adooq's MD-224 has been cited by 1 publications
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
MD-224
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Size Price Stock Qty
5mg
$180.00
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10mg
$320.00
In stock
50mg
$880.00
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's MD-224 has been cited by 1 publications
  • Lingling Chen, .et al. , Biochem Pharmacol, 2024, Nov 29:232:116688 PMID: 39617210
    • Biological Activity
    Discription MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
    Targets
    Target Value
    Product Information
    Catalog Num A18712
    Formula C48H43Cl2FN6O6
    Molecular Weight 889.8
    CAS Number 2136247-12-4
    SMILES FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O
    Synonyms MD224, MD 224
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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    Apoptosis > MDM2
    PROTACs > PROTAC Degrader
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