MD-224

Catalog No.: A18712
MDM2 degrader
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
Grouped product items
Product Name Price Stock Qty
MD-224 5mg
$180.00
In stock
MD-224 10mg
$320.00
In stock
MD-224 50mg
$880.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
Targets
Target Value
Product Information
Catalog Num A18712
Formula C48H43Cl2FN6O6
Molecular Weight 889.8
CAS Number 2136247-12-4
SMILES FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O
Synonyms MD224, MD 224
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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