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Biological Activity
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.24 mL | 56.19 mL | 112.38 mL |
| 0.5 mM | 2.25 mL | 11.24 mL | 22.48 mL |
| 1 mM | 1.12 mL | 5.62 mL | 11.24 mL |
| 5 mM | 0.22 mL | 1.12 mL | 2.25 mL |
*The above data is based on the productmolecular weight 889.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18712 |
|---|---|
| Actions | Degrader |
| CAS No. | 2136247-12-4 |
| Formula | C48H43Cl2FN6O6 |
| M. Wt | 889.8 |
| Purity | >98% |
| Synonyms | MD224, MD 224 |
| SMILES | FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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