MD-224

Catalog No.: A18712

MDM2 degrader

MD-224

MD-224 Chemical Structure

CAS NO. 2136247-12-4

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.24 mL 56.19 mL 112.38 mL
0.5 mM 2.25 mL 11.24 mL 22.48 mL
1 mM 1.12 mL 5.62 mL 11.24 mL
5 mM 0.22 mL 1.12 mL 2.25 mL

*The above data is based on the productmolecular weight 889.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18712
Actions Degrader
M. Wt 889.8
Formula C48H43Cl2FN6O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2136247-12-4
Synonyms MD224, MD 224
SMILES FC1=C(Cl)C=CC=C1[[email protected]@H]2[[email protected]@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[[email protected]]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O

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