MD5 is a selective inhibitor of TMPRSS6, demonstrating an IC50 of 22 nM and a Ki of 3.4 nM for recombinant human TMPRSS6. It shows limited inhibition of Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM, and a weak effect on thrombin (Ki of 120 nM). Due to its favorable target specificity and initial drug-like properties, MD5 is suitable for research into iron overload diseases, including hereditary hemochromatosis and β-thalassemia.
MD5 is a selective inhibitor of TMPRSS6, demonstrating an IC50 of 22 nM and a Ki of 3.4 nM for recombinant human TMPRSS6. It shows limited inhibition of Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM, and a weak effect on thrombin (Ki of 120 nM). Due to its favorable target specificity and initial drug-like properties, MD5 is suitable for research into iron overload diseases, including hereditary hemochromatosis and β-thalassemia.
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