Mexiletine is an orally active antiarrhythmic agent that primarily targets sodium channels to exert its effects, with IC50 values of 75±8 μM for tonic block and 23.6±2.8 μM for use-dependent block. In addition to its antiarrhythmic properties, Mexiletine has demonstrated efficacy in treating myotonia and neuropathic pain. This compound is valuable for research applications in both cardiovascular and neurological studies, providing insights into channelopathies and pain mechanisms.
Mexiletine is an orally active antiarrhythmic agent that primarily targets sodium channels to exert its effects, with IC50 values of 75±8 μM for tonic block and 23.6±2.8 μM for use-dependent block. In addition to its antiarrhythmic properties, Mexiletine has demonstrated efficacy in treating myotonia and neuropathic pain. This compound is valuable for research applications in both cardiovascular and neurological studies, providing insights into channelopathies and pain mechanisms.
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