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mG2N001

mGluR2 Negative Allosteric Modulator

mG2N001 is a negative allosteric modulator of the metabotropic glutamate receptor mGluR2, exhibiting an IC50 of 93 nM and a binding affinity (Ki) of 63 nM. This compound demonstrates significant biological activity by modulating glutamatergic signaling pathways, making it valuable for neurological research. Additionally, its radioisotope [11C]mG2N001 is suitable for PET imaging, providing high brain heterogeneity and penetration, allowing for selective accumulation in mGluR2-rich regions, which enhances imaging contrast in neurobiological studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	2760515-88-4
Applications	mGluR2 Negative Allosteric Modulator
Formula	C₁₈H₁₉FN₂O₃
Molecular Weight	330.35
SMILES	O=C(C1=NC2=C(C(C3=C(F)C=C(OC)C=C3)=C1)CCC(C)(C)O2)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.