MGD-28 is a potent IKAROS protein degrader that functions through Cereblon (CRBN)-dependent mechanisms. It effectively degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), along with CK1α (DC50=7.8 nM), in a dose-dependent manner. MGD-28 exhibits significant antiproliferative activity, making it a valuable tool for research in multiple myeloma and related hematological malignancies.
MGD-28 is a potent IKAROS protein degrader that functions through Cereblon (CRBN)-dependent mechanisms. It effectively degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), along with CK1α (DC50=7.8 nM), in a dose-dependent manner. MGD-28 exhibits significant antiproliferative activity, making it a valuable tool for research in multiple myeloma and related hematological malignancies.
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