MGD-4 is an orally bioavailable IKAROS protein degrader that operates via Cereblon (CRBN) dependence, demonstrating effective degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM). It exhibits significant anti-proliferative activity against multiple myeloma, making it a valuable tool for research into therapies targeting hematological malignancies. This compound is ideal for studies investigating the role of IKAROS family proteins in cancer biology and the development of protein degradation strategies.
MGD-4 is an orally bioavailable IKAROS protein degrader that operates via Cereblon (CRBN) dependence, demonstrating effective degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM). It exhibits significant anti-proliferative activity against multiple myeloma, making it a valuable tool for research into therapies targeting hematological malignancies. This compound is ideal for studies investigating the role of IKAROS family proteins in cancer biology and the development of protein degradation strategies.
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