MI-2 (Menin-MLL inhibitor 2)

Catalog No.: A12929

Menin-MLL interaction inhibitor

MI-2 (Menin-MLL inhibitor 2)

MI-2 (Menin-MLL inhibitor 2) Chemical Structure

CAS NO. 1271738-62-5

MI-2 (Menin-MLL inhibitor 2) specifically binds to Menin and inhibits Menin??s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein?Cmediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $140.00

Special Price $112.00

10 mg

Regular Price: $200.00

Special Price $160.00

25 mg

Regular Price: $390.00

Special Price $312.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

MI-2 (Menin-MLL inhibitor 2) specifically binds to Menin and inhibits Menin??s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein?Cmediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins.
Targets
Menin-MLL Menin-MLL
N/A446 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.63 mL 133.14 mL 266.28 mL
0.5 mM 5.33 mL 26.63 mL 53.26 mL
1 mM 2.66 mL 13.31 mL 26.63 mL
5 mM 0.53 mL 2.66 mL 5.33 mL

*The above data is based on the productmolecular weight 375.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A12929
Actions No
M. Wt 375.55
Formula C18H25N5S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1271738-62-5
Synonyms Menin-MLL inhibitor 2
SMILES CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C

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