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Biological Activity
MI-2 (Menin-MLL inhibitor 2) specifically binds to Menin and inhibits Menin??s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein?Cmediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins.
Targets
| Menin-MLL | Menin-MLL | |||
| N/A | 446 nM |
| In vitro (25°C) | DMSO | Warmed: 71 mg/mL (189.05 mM) | |
| Water | Insoluble | ||
| Ethanol | 71 mg/mL (189.05 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.63 mL | 133.14 mL | 266.28 mL |
| 0.5 mM | 5.33 mL | 26.63 mL | 53.26 mL |
| 1 mM | 2.66 mL | 13.31 mL | 26.63 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.33 mL |
*The above data is based on the productmolecular weight 375.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12929 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1271738-62-5 |
| Formula | C18H25N5S2 |
| M. Wt | 375.55 |
| Purity | >98% |
| Synonyms | Menin-MLL inhibitor 2 |
| SMILES | CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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