SARS-CoV

Aloin B (Isobarbaloin) is an orally active inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with reported IC50 values of 16.08 μM for hydrolytic activity and 17.51 μM for deubiquitinase activity. This compound demonstrates biological activity in anti-inflammatory pathways and tumor promotion inhibition, making it valuable for research in cancer biology and COVID-19. Additionally, Aloin B is metabolized by intestinal flora to produce aloe-emodin-9-anthrone, which may contribute to its laxative effects.