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- Shuang Liang, .et al. Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b, Cardiovasc Ther, 2022, Apr 7;2022:7145699 PMID: 35474714
Biological Activity
Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes.
Targets
| Progesterone receptor | Glucocorticoid receptor | |||
| 0.2 nM | 2.6 nM |
| In vitro | DMSO | 77 mg/mL (179.24 mM) | |
| Water | Insoluble | ||
| Ethanol | 17 mg/mL (39.57 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.28 mL | 116.39 mL | 232.77 mL |
| 0.5 mM | 4.66 mL | 23.28 mL | 46.55 mL |
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10591 |
|---|---|
| CAS No. | 84371-65-3 |
| Formula | C29H35NO2 |
| M. Wt | 429.6 |
| Purity | >98% |
| Synonyms | RU-486, Mifegyne |
| SMILES | CC#C[[email protected]@]1(CC[[email protected]@H]2[[email protected]@]1(C[[email protected]@H](C3=C4CCC(=O)C=C4CC[[email protected]@H]23)C5=CC=C(C=C5)N(C)C)C)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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