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- Bhavik Patel, .et al. Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis, Pharmacol Res Perspect, 2020, 8 (1), e00564 PMID: 32030913
Biological Activity
Mirabegron is a potent bladder relaxant and reagent for diabetes remedy.
Targets
| β3-adrenoceptor | ||||
| 22.4 nM(EC50) |
| In vitro (25°C) | DMSO | 70 mg/mL (176.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 7 mg/mL (17.65 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.22 mL | 126.1 mL | 252.2 mL |
| 0.5 mM | 5.04 mL | 25.22 mL | 50.44 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
*The above data is based on the productmolecular weight 396.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12861 |
|---|---|
| Actions | Activator |
| CAS No. | 223673-61-8 |
| Formula | C21H24N4O2S |
| M. Wt | 396.51 |
| Purity | >98% |
| SMILES | C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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