Fig. 1 · Structure
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Mitragynine pseudoindoxyl
Opioid Receptor Modulator
Mitragynine pseudoindoxyl functions primarily as a μ-opioid receptor agonist with a Ki of 0.8 nM, while also acting as an antagonist at the δ-opioid receptor (Ki=3.0 nM). This compound exhibits moderate affinity for the κ-opioid receptor (Ki=24 nM) and operates through G protein-mediated signaling without β-arrestin-2 recruitment. Characterized by significant analgesic effects via a mixed μ-agonist/δ-antagonist mechanism, Mitragynine pseudoindoxyl demonstrates a reduced risk of common opioid side effects such as respiratory depression and dependency. Its potential applications include the management of hyperactivity and gastrointestinal transit inhibition, making it a candidate for therapeutic pain relief.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2035457-43-1 |
| Applications | Opioid Receptor Modulator |
| Formula | C23H30N2O5 |
| Molecular Weight | 414.49 |
| SMILES | O=C1[C@@]2(NC3=CC=CC(OC)=C31)[C@@]4([H])N(C[C@H]([C@H](C4)/C(C(OC)=O)=C\OC)CC)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.