MK-6096 (Filorexant)

Catalog No.: A13168

Orexin receptor antagonist

MK-6096 (Filorexant)

MK-6096 (Filorexant) Chemical Structure

CAS NO. 1088991-73-4

MK6096, also known as filorexant, is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. MK-6096 demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes.

Availability: In stock

Package Price Qty
5 mg
$75.00
25 mg
$270.00
100 mg
$650.00
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Biological Activity

MK6096, also known as filorexant, is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. MK-6096 demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.78 mL 118.91 mL 237.82 mL
0.5 mM 4.76 mL 23.78 mL 47.56 mL
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL

*The above data is based on the productmolecular weight 420.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13168
Actions Antagonist
M. Wt 420.48
Formula C24H25FN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1088991-73-4
Synonyms MK6096, MK-6096, MK 6096
SMILES CC1=CC=C(C2=NC=CC=N2)C(C(N3C[[email protected]@H](COC4=NC=C(F)C=C4)CC[[email protected]@H]3C)=O)=C1

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