MKT 077

Catalog No.: A12388

HSP70 Inhibitor

MKT 077 Chemical Structure

CAS NO. 147366-41-4

Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$120.00
25 mg
$200.00
100 mg
$350.00
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Biological Activity

Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.15 mL 115.74 mL 231.48 mL
0.5 mM 4.63 mL 23.15 mL 46.3 mL
1 mM 2.31 mL 11.57 mL 23.15 mL
5 mM 0.46 mL 2.31 mL 4.63 mL

*The above data is based on the productmolecular weight 432. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12388
Actions Inhibitor
M. Wt 432
Formula C21H22ClN3OS2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 147366-41-4
Synonyms MKT077, MKT-077
SMILES CCN1/C(=C/C2=CC=CC=[N+]2CC)/S/C(=C/3\N(C4=CC=CC=C4S3)C)/C1=O.[Cl-]

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