ML-211 is a carbamate-based inhibitor targeting acyl-protein thioesterase 1 (APT1) and lysophospholipase 1 (LYPLA1), with an IC50 of 17 nM, as well as lysophospholipase 2 (LYPLA2) with an IC50 of 30 nM. Additionally, it inhibits the serine hydrolase ABHD11 at an IC50 of 10 nM while demonstrating greater than 50-fold selectivity for LYPLA in a diverse panel of 20 serine hydrolases. ML-211 is valuable for research involving lipid metabolism and signaling pathways, particularly those associated with phospholipase activity.
ML-211 is a carbamate-based inhibitor targeting acyl-protein thioesterase 1 (APT1) and lysophospholipase 1 (LYPLA1), with an IC50 of 17 nM, as well as lysophospholipase 2 (LYPLA2) with an IC50 of 30 nM. Additionally, it inhibits the serine hydrolase ABHD11 at an IC50 of 10 nM while demonstrating greater than 50-fold selectivity for LYPLA in a diverse panel of 20 serine hydrolases. ML-211 is valuable for research involving lipid metabolism and signaling pathways, particularly those associated with phospholipase activity.
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