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Biological Activity
ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.03 mL | 95.13 mL | 190.26 mL |
| 0.5 mM | 3.81 mL | 19.03 mL | 38.05 mL |
| 1 mM | 1.9 mL | 9.51 mL | 19.03 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.81 mL |
*The above data is based on the productmolecular weight 525.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21633 |
|---|---|
| Actions | Agonist |
| CAS No. | 1338824-21-7 |
| Formula | C31H31N3O5 |
| M. Wt | 525.59 |
| Purity | >98% |
| Synonyms | NCGC00242364, NCGC 00242364, NCGC-00242364; ANTAG3, ANTAG-3; ML 224, ML-224 |
| SMILES | CC(NC1=CC(C)=C(OCC2=CC(C(N3CC4=CC=CO4)NC5=C(C=CC=C5)C3=O)=CC=C2OC)C(C)=C1)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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