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ML256

Catalog No.: A77176
Lp-PLA2 Inhibitor
ML256 is a covalent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), a key enzyme involved in lipid metabolism and inflammation. This compound exhibits biological activity by selectively targeting Lp-PLA2, making it valuable in the investigation of neoplasms with constitutively active variants of KRAS or HRAS. It is useful for research applications focusing on cancer biology and the modulation of inflammatory pathways.
ML256 2415152-07-5 Lp-PLA2 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionML256 is a covalent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), a key enzyme involved in lipid metabolism and inflammation. This compound exhibits biological activity by selectively targeting Lp-PLA2, making it valuable in the investigation of neoplasms with constitutively active variants of KRAS or HRAS. It is useful for research applications focusing on cancer biology and the modulation of inflammatory pathways.
Product Information
Catalog NumA77176
FormulaC26H24N4O2
Molecular Weight424.49
CAS Number2415152-07-5
SMILESO=C(N1CCN(CC1)C2=CC(C)=NC3=C2C=CC=C3)OC4=CC=C(C5=CC=CC=C5)C=N4
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Metabolism > Phospholipases