ML301

Catalog No.: A60810
GPR Agonist
ML301 is a small molecule G-protein coupled receptor (GPCR) agonist that activates GPR signaling pathways. This compound exhibits potent biological activity, effectively competing for 125I-NT binding and demonstrating inhibition by SR142948A with an IC50 of approximately 63 nM. ML301 is useful for research applications exploring GPCR mechanisms, signal transduction, and receptor pharmacology.
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5mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionML301 is a small molecule G-protein coupled receptor (GPCR) agonist that activates GPR signaling pathways. This compound exhibits potent biological activity, effectively competing for 125I-NT binding and demonstrating inhibition by SR142948A with an IC50 of approximately 63 nM. ML301 is useful for research applications exploring GPCR mechanisms, signal transduction, and receptor pharmacology.
Product Information
Catalog NumA60810
FormulaC27H27ClN4O5
Molecular Weight522.98
CAS Number1531633-84-7
SMILESCC(C)C[C@@H](C(O)=O)NC(C1=CN(C2=CC=NC3=C2C=CC(Cl)=C3)C(C4=C(C=CC=C4OC)OC)=N1)=O
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