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ML335 is a potent and selective TREK-1/2 Activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.
| In vitro | DMSO | 74 mg/mL (198.25 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (13.39 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.79 mL | 133.96 mL | 267.92 mL |
| 0.5 mM | 5.36 mL | 26.79 mL | 53.58 mL |
| 1 mM | 2.68 mL | 13.4 mL | 26.79 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
*The above data is based on the productmolecular weight 373.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16957 |
|---|---|
| Actions | Activator |
| CAS No. | 825658-06-8 |
| Formula | C15H14Cl2N2O3S |
| M. Wt | 373.24 |
| Purity | >98% |
| Synonyms | ML-335, ML 335 |
| SMILES | O=C(NCC1=CC=C(Cl)C=C1Cl)C2=CC=C(NS(=O)(C)=O)C=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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