ML348

Catalog No.: A16338

LYPLA1 inhibitor

ML348

ML348 Chemical Structure

CAS NO. 899713-86-1

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $90.00

Special Price $72.00

50 mg

Regular Price: $270.00

Special Price $216.00

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Biological Activity

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.
In vitro DMSO 77 mg/mL (185.19 mM)
Water Insoluble
Ethanol 9 mg/mL (21.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.05 mL 120.25 mL 240.51 mL
0.5 mM 4.81 mL 24.05 mL 48.1 mL
1 mM 2.41 mL 12.03 mL 24.05 mL
5 mM 0.48 mL 2.41 mL 4.81 mL

*The above data is based on the productmolecular weight 415.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16338
Actions Inhibitor
CAS No. 899713-86-1
Formula C18H17ClF3N3O3
M. Wt 415.79
Purity >98%
Synonyms ML-348, ML 348
SMILES ClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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