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Biological Activity
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
| In vitro | DMSO | 62 mg/mL (185.44 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.91 mL | 149.56 mL | 299.11 mL |
| 0.5 mM | 5.98 mL | 29.91 mL | 59.82 mL |
| 1 mM | 2.99 mL | 14.96 mL | 29.91 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.98 mL |
*The above data is based on the productmolecular weight 334.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18622 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 381168-77-0 |
| Formula | C19H12F2N4 |
| M. Wt | 334.32 |
| Purity | >98% |
| Synonyms | ML-367, ML 367 |
| SMILES | FC1=CC(NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42)=CC=C1F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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