ML418

Catalog No.: A18426

Kir7.1 potassium channels blocker

ML418

ML418 Chemical Structure

CAS NO. 1928763-08-9

ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $350.00

Special Price $280.00

10 mg

Regular Price: $650.00

Special Price $520.00

50 mg

Regular Price: $2,000.00

Special Price $1,600.00

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Biological Activity

ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.46 mL 132.32 mL 264.64 mL
0.5 mM 5.29 mL 26.46 mL 52.93 mL
1 mM 2.65 mL 13.23 mL 26.46 mL
5 mM 0.53 mL 2.65 mL 5.29 mL

*The above data is based on the productmolecular weight 377.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18426
Actions Blocker
CAS No. 1928763-08-9
Formula C19H24ClN3O3
M. Wt 377.87
Purity >98%
Synonyms ML418; ML-418; ML 418
SMILES O=C(OC(C)C)NC1CCN(CC2=CC(Cl)=C3C=CC=NC3=C2O)CC1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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