ML786 is a potent Raf inhibitor with oral bioavailability, demonstrating IC50 values of 2.1 nM for V600EΔB-Raf, 4.2 nM for wild-type B-Raf, and 2.5 nM for C-Raf. Additionally, ML786 exhibits inhibitory effects on Abl-1, DDR2, EPHA2, KDR, and RET, with IC50 values under 0.5 nM, 7.0 nM, 11 nM, 6.2 nM, and 0.8 nM, respectively. This compound is suitable for research applications focused on cancer biology, helping to advance understanding of therapeutic targets within malignancies.
ML786 is a potent Raf inhibitor with oral bioavailability, demonstrating IC50 values of 2.1 nM for V600EΔB-Raf, 4.2 nM for wild-type B-Raf, and 2.5 nM for C-Raf. Additionally, ML786 exhibits inhibitory effects on Abl-1, DDR2, EPHA2, KDR, and RET, with IC50 values under 0.5 nM, 7.0 nM, 11 nM, 6.2 nM, and 0.8 nM, respectively. This compound is suitable for research applications focused on cancer biology, helping to advance understanding of therapeutic targets within malignancies.
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