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Biological Activity
MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki < 1 nM in WDR5 binding assay, which is >200 times more potent than the ARA peptide.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.76 mL | 63.79 mL | 127.58 mL |
| 0.5 mM | 2.55 mL | 12.76 mL | 25.52 mL |
| 1 mM | 1.28 mL | 6.38 mL | 12.76 mL |
| 5 mM | 0.26 mL | 1.28 mL | 2.55 mL |
*The above data is based on the productmolecular weight 783.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21941 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1883545-52-5 |
| Formula | C37H50F5N7O6 |
| M. Wt | 783.83 |
| Purity | >98% |
| Synonyms | HMTase Inhibitor IX TFA, MM102, MM 102 |
| SMILES | O=C(C1(NC([[email protected]@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3.FC(F)(F)C(O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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