MM-433593 is a selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1), targeting the endocannabinoid system to modulate pain and inflammation pathways. It demonstrates effective pharmacokinetic properties, including a biphasic elimination profile characterized by a rapid distribution and a slower elimination phase. With moderate oral bioavailability (14-21%), MM-433593 undergoes metabolism primarily through the oxidation of its indole ring's methyl group, yielding various sulfate, glucuronide, and glutathione-conjugated metabolites, making it a valuable tool for investigating FAAH-related biological processes and therapeutic applications.
MM-433593 is a selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1), targeting the endocannabinoid system to modulate pain and inflammation pathways. It demonstrates effective pharmacokinetic properties, including a biphasic elimination profile characterized by a rapid distribution and a slower elimination phase. With moderate oral bioavailability (14-21%), MM-433593 undergoes metabolism primarily through the oxidation of its indole ring's methyl group, yielding various sulfate, glucuronide, and glutathione-conjugated metabolites, making it a valuable tool for investigating FAAH-related biological processes and therapeutic applications.
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