MMG-0358 is a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 2 nM in cellular assays against murine IDO1 (mIDO1) and 80 nM against human IDO1 (hIDO1). Additionally, it displays IC50 values of 330 nM and 71 nM in enzymatic assays of hIDO1 at pH 6.5 and pH 7.4, respectively. This compound is a valuable tool for studying immune regulation and may have applications in cancer immunotherapy and related research fields.
MMG-0358 is a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 2 nM in cellular assays against murine IDO1 (mIDO1) and 80 nM against human IDO1 (hIDO1). Additionally, it displays IC50 values of 330 nM and 71 nM in enzymatic assays of hIDO1 at pH 6.5 and pH 7.4, respectively. This compound is a valuable tool for studying immune regulation and may have applications in cancer immunotherapy and related research fields.
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