Mobocertinib mesylate

Catalog No.: A28822
EGFR/HER2 Inhibitor
Mobocertinib mesylate is an orally active and irreversible inhibitor of EGFR and HER2. It exhibits potent inhibition of oncogenic variants with activating EGFR exon 20 insertion mutations while showing selectivity for wild-type EGFR. This reagent is primarily utilized in research focused on non-small cell lung cancer (NSCLC).
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMobocertinib mesylate is an orally active and irreversible inhibitor of EGFR and HER2. It exhibits potent inhibition of oncogenic variants with activating EGFR exon 20 insertion mutations while showing selectivity for wild-type EGFR. This reagent is primarily utilized in research focused on non-small cell lung cancer (NSCLC).
Product Information
Catalog NumA28822
FormulaC33H43N7O7S
Molecular Weight681.80
CAS Number2389149-85-1
SMILESO=C(C1=CN=C(NC2=CC(NC(C=C)=O)=C(N(CCN(C)C)C)C=C2OC)N=C1C3=CN(C)C4=C3C=CC=C4)OC(C)C.O=S(O)(C)=O
SynonymsTAK-788 mesylate; AP32788 mesylate
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