Mofegiline hydrochloride is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting a significant preference over monoamine oxidase A (MAO-A) with IC50 values of 3.6 nM and 680 nM, respectively. This compound also inhibits semicarbazide-sensitive amine oxidase (SSAO). Mofegiline hydrochloride is utilized in research focused on neurodegenerative disorders and the modulation of neurotransmitter levels. Its specific action on MAO-B makes it a valuable tool in studies addressing dopamine metabolism and potential therapeutic strategies for Parkinson's disease.
Mofegiline hydrochloride is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting a significant preference over monoamine oxidase A (MAO-A) with IC50 values of 3.6 nM and 680 nM, respectively. This compound also inhibits semicarbazide-sensitive amine oxidase (SSAO). Mofegiline hydrochloride is utilized in research focused on neurodegenerative disorders and the modulation of neurotransmitter levels. Its specific action on MAO-B makes it a valuable tool in studies addressing dopamine metabolism and potential therapeutic strategies for Parkinson's disease.
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