Monoamine Oxidase B inhibitor 5 is a selective and reversible inhibitor of monoamine oxidase B (hMAO-B) with an IC50 of 67.3 nM and a Ki value of 82.5 nM. This compound demonstrates favorable pharmacokinetic properties and low toxicity in rat models. Additionally, Monoamine Oxidase B inhibitor 5 has shown efficacy in alleviating MPTP-induced motor impairment in Parkinson’s disease mouse models, with the capability to cross the blood-brain barrier. This makes it a valuable tool for research in neurodegenerative diseases and MAO-B related pathways.
Monoamine Oxidase B inhibitor 5 is a selective and reversible inhibitor of monoamine oxidase B (hMAO-B) with an IC50 of 67.3 nM and a Ki value of 82.5 nM. This compound demonstrates favorable pharmacokinetic properties and low toxicity in rat models. Additionally, Monoamine Oxidase B inhibitor 5 has shown efficacy in alleviating MPTP-induced motor impairment in Parkinson’s disease mouse models, with the capability to cross the blood-brain barrier. This makes it a valuable tool for research in neurodegenerative diseases and MAO-B related pathways.
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