Fig. 1 · Structure
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Mps1/TTK-IN-1
Cat. No.
A55077
CAS
1202055-39-7
Mps1 Inhibitor
Mps1/TTK-IN-1 is a potent Mps1 kinase inhibitor that specifically binds to the ATP-binding pocket of the enzyme with an IC50 of 9.2 nM and a Kd of 1.6 nM. It effectively inhibits Mps1 activity, including in drug-resistant mutants (C604Y and C604W) with IC50 values of 170 nM and 19 nM, respectively. By blocking the phosphorylation of the kinetochore protein KNL1, Mps1/TTK-IN-1 disrupts spindle assembly checkpoint function and hinders proper chromosome separation, ultimately inhibiting mitosis and tumor cell proliferation, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1202055-39-7 |
| Applications | Mps1 Inhibitor |
| Formula | C33H40N8O2 |
| Molecular Weight | 580.72 |
| SMILES | O=C(C1=NN(C)C2=C1CCC3=C2N=C(NC4=CC=C(N5CCN(CC5)C)C=C4OC)N=C3)NC6=C(CC)C=CC=C6CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.