MRK-016

Name: MRK-016
Brand: Adooq Bioscience
SKU: A12046
Rating: 5 (288 reviews)

Catalog No.: A12046

GABAA α5 receptor agonist

MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.

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MRK-016 342652-67-9 GABAA α5 receptor agonist

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Grouped product items
Size	Price	Stock
5mg	$85.00	In stock
10mg	$150.00	In stock
50mg	$455.00	In stock
100mg	$780.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.

Product Information

Catalog Num	A12046
Formula	C17H20N8O2
Molecular Weight	368.39
CAS Number	342652-67-9
SMILES	CN1N=CN=C1COC2=NN3C(C4=NOC(C)=C4)=NN=CC3=C2C(C)(C)C
Synonyms	MRK 016, MRK016
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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