MRK-623 is a potent GABAA receptor agonist with high affinity, exhibiting Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for the α1, α2, α3, and α5 subtypes, respectively. This compound demonstrates significant anxiolytic effects, making it a valuable tool for research in anxiety disorders and related neurological studies. Its oral bioactivity further enhances its utility in pharmacological investigations.
MRK-623 is a potent GABAA receptor agonist with high affinity, exhibiting Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for the α1, α2, α3, and α5 subtypes, respectively. This compound demonstrates significant anxiolytic effects, making it a valuable tool for research in anxiety disorders and related neurological studies. Its oral bioactivity further enhances its utility in pharmacological investigations.
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