MRS1334 is a potent and selective antagonist of the human adenosine A3 receptor, exhibiting a Ki of 2.69 nM. This compound effectively disrupts the cardioprotective effects of Cl-IB-MECA, resulting in significant bradycardia and elevated ST segment changes. Additionally, MRS1334 features an alkyne group that enables its use in click chemistry, specifically facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This property positions MRS1334 as a valuable tool in chemical biology and therapeutic research.
MRS1334 is a potent and selective antagonist of the human adenosine A3 receptor, exhibiting a Ki of 2.69 nM. This compound effectively disrupts the cardioprotective effects of Cl-IB-MECA, resulting in significant bradycardia and elevated ST segment changes. Additionally, MRS1334 features an alkyne group that enables its use in click chemistry, specifically facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This property positions MRS1334 as a valuable tool in chemical biology and therapeutic research.
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