Mufemilast is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 80-120 nM. This compound effectively modulates cytokines associated with Behçet's syndrome and exhibits significant inhibition of TNF-α, a key pro-inflammatory cytokine involved in the pathology of psoriasis. Mufemilast is suitable for research applications related to autoimmune conditions, including rheumatoid arthritis, psoriasis, and Behçet’s syndrome.
Mufemilast is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 80-120 nM. This compound effectively modulates cytokines associated with Behçet's syndrome and exhibits significant inhibition of TNF-α, a key pro-inflammatory cytokine involved in the pathology of psoriasis. Mufemilast is suitable for research applications related to autoimmune conditions, including rheumatoid arthritis, psoriasis, and Behçet’s syndrome.
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