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N-Boc-SBP-0636457-O-C3-COOH

Catalog No.: A80156
E3 Ligase Ligand-Linker Conjugates
N-Boc-SBP-0636457-O-C3-COOH is a synthesized E3 ligase ligand-linker conjugate, designed to facilitate targeted protein degradation via PROTAC technology. This compound incorporates an IAP ligand and a linker, enabling the development of Bcl-xL degraders. It is particularly useful in studies aimed at elucidating the role of Bcl-xL in cellular processes and therapeutic applications in cancer research.
N-Boc-SBP-0636457-O-C3-COOH 2450350-91-9 E3 Ligase Ligand-Linker Conjugates
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN-Boc-SBP-0636457-O-C3-COOH is a synthesized E3 ligase ligand-linker conjugate, designed to facilitate targeted protein degradation via PROTAC technology. This compound incorporates an IAP ligand and a linker, enabling the development of Bcl-xL degraders. It is particularly useful in studies aimed at elucidating the role of Bcl-xL in cellular processes and therapeutic applications in cancer research.
Product Information
Catalog NumA80156
FormulaC34H50N4O9
Molecular Weight658.78
CAS Number2450350-91-9
SMILESO=C([C@@H]1C(C[C@@](N1C2=O)(OCC[C@@H]2NC([C@H](C)N(C(OC(C)(C)C)=O)C)=O)[H])(C)C)N[C@@H]3CCCC4=C3C=CC(OCCCC(O)=O)=C4
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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PROTAC > E3 Ligase Ligand-Linker Conjugate