N-Desmethyl-Apalutamide is an active metabolite of Apalutamide, primarily functioning as an androgen receptor antagonist. This compound exhibits moderate potency in inhibiting androgen receptor activity and accounts for approximately one-third of the pharmacological effect of its parent compound. N-Desmethyl-Apalutamide is predominantly metabolized by CYP2C8 and CYP3A4 enzymes, while also serving as a moderate to strong inducer of CYP3A4 and CYP2B6. Its high plasma protein-binding capacity further enhances its utility in research applications related to androgen receptor modulation and therapeutic exploration in prostate cancer treatment.
N-Desmethyl-Apalutamide is an active metabolite of Apalutamide, primarily functioning as an androgen receptor antagonist. This compound exhibits moderate potency in inhibiting androgen receptor activity and accounts for approximately one-third of the pharmacological effect of its parent compound. N-Desmethyl-Apalutamide is predominantly metabolized by CYP2C8 and CYP3A4 enzymes, while also serving as a moderate to strong inducer of CYP3A4 and CYP2B6. Its high plasma protein-binding capacity further enhances its utility in research applications related to androgen receptor modulation and therapeutic exploration in prostate cancer treatment.
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