N3-C4-NHS ester is a noncleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), specifically targeting azide groups. This compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, enabling efficient conjugation. Additionally, N3-C4-NHS ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it highly versatile for bioconjugation applications in chemical biology and therapeutic development.
N3-C4-NHS ester is a noncleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), specifically targeting azide groups. This compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, enabling efficient conjugation. Additionally, N3-C4-NHS ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it highly versatile for bioconjugation applications in chemical biology and therapeutic development.
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