N3-Ph-NHS ester is a non-cleavable linker for antibody-drug conjugates (ADCs), designed to facilitate the synthesis of these complex bioconjugates. As a click chemistry reagent, it features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biologists engaged in ADC development.
N3-Ph-NHS ester is a non-cleavable linker for antibody-drug conjugates (ADCs), designed to facilitate the synthesis of these complex bioconjugates. As a click chemistry reagent, it features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biologists engaged in ADC development.
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